This medicine, like Alumina, seems to produce a peculiar kind of paralytic weakness of the muscles in all parts of the body, a sort of lack of tone. The extremities are weak. This weakness is felt especially in the rectum and bladder. The stool becomes impacted from want of ability of the rectum and colon to expel their contents. The bladder is also slowed down in its action, and i: is with great difficulty that the urine is voided. After urinating, the bladder often remains half full. The urine is very slow to start, and when the patient stands to urinate the urine falls down perpendicularly, as in Hepar. From this we see the sluggish action. The paralytic condition extends also to the veins producing a vaso-motor paralysis. Another peculiar condition running through the remedy is the tendency to induration wherever there is an inflamed surface. All remedies that have this in their nature relate more or less to cancerous affections, because in cancer we have as the most natural feature a tendency to induration. Ulcers are common in Alumen, and this induration underlies the ulcer; ulcers with indurated base. Or little scales may appear upon the skin where the circulation is feeble, over cartilaginous portions for instance, and a great thick indurated mass forms. Infiltration takes place under this crust, the crust keeps coming off, and a lack of healing follows because of the weakness of the tissues from a vaso-motor paralysis. Epithelioma is scarcely more than that, and so we have in this remedy features like epithelioma and other cancerous affections. What is the scirrhus but a peculiar form of induration? When the economy takes on a low type of life, a low form of tissue making, and the tissues inflame and upon the slightest provocation indurate we can see that this is a kind of constitution that is predisposed to deep-seated troubles, to phthisis, Bright's disease, diabetes, cancer, etc. We are on the border line of ultimates and something is going to happen. This remedy leads the economy into such a state of disorder, a low type of tissue making is found, and many of these indurations will have cancer as an ultimate. This is a long acting antipsoric remedy.